Complication-Centric Model

Adiposity-Based Chronic Disease.
Beyond BMI, Built for Metabolic Health.

A clinical model that treats obesity as a disease and supports metabolic health assessment, metabolic health checks, and clearer metabolic syndrome risk stratification.

The ABCD Framework

Understand the 4 stages of adiposity-based chronic disease.

Clinical Framework

What Is Adiposity-Based
Chronic Disease?

ABCD is a complication-centric model. By shifting focus from weight to pathophysiology, we move beyond BMI toward data-driven systemic health.

01

At Risk

Early detection of metabolic predisposition and adiposity pathophysiology.

Primary Prevention
02

Mild/Moderate

Targeted intervention for subclinical complications and organ stress.

Secondary Prevention
03

Established

Advanced management of manifest clinical complications.

Active Management
04

Advanced

Comprehensive tertiary care for structural damage and functional impairment.

Tertiary Intervention
Protocol Focus

Precision Mapping

Weight is a proxy, not a diagnosis. By evaluating adipose tissue dysfunction, clinicians can prescribe interventions tailored to metabolic phenotype.

Clinical Precision

Targeted titration based on severity.

Systemic Impact

Focus on cardiovascular restoration.

"The shift to ABCD allows for a medically relevant diagnosis of obesity as a chronic disease."
ABCD
Clinical Standard

Diagnostic
Precision.

Moving beyond mass to metabolic mapping. A comprehensive evaluation of five critical systemic drivers.

Metabolic Drivers
Diagnostic Unit

Metabolic Drivers

Insulin & Lipid Pathways

Biomechanical Stress
Diagnostic Unit

Biomechanical Stress

Skeletal Integrity

Cardiometabolic
Diagnostic Unit

Cardiometabolic

Vascular Precision

Adipose Tissue
Diagnostic Unit

Adipose Tissue

Pathophysiological Analysis

Neurometabolic
Diagnostic Unit

Neurometabolic

Systemic Signaling

Inquire Clinical Integration.

Have questions about the ABCD staging protocol or interested in collaboration? Our medical desk is here to assist.

Primary Contact

[email protected]

ABCD Topic Hub

Explore key guides on adiposity-based chronic disease, staging, symptoms, treatment, prevention, and cardiometabolic risk.

ABCD Questions

What is adiposity-based chronic disease?

Adiposity-Based Chronic Disease (ABCD) is a clinical framework that classifies disease by complication severity across organ systems rather than BMI alone. It recognizes obesity as a disease and enables personalized metabolic health management through staged interventions.

Why is obesity considered a disease in the ABCD framework?

The ABCD model defines obesity as a disease because it focuses on the metabolic dysfunction and complications caused by adiposity, not just excess weight. This includes metabolic, biomechanical, cardiovascular, and psychological complications that require medical management.

What is metabolic health assessment under ABCD?

Metabolic health assessment in ABCD evaluates insulin resistance, lipid profiles, glucose control, and inflammatory markers to determine disease severity and treatment needs, rather than relying on BMI or weight alone.

How does ABCD address metabolic syndrome risk?

ABCD identifies and stages metabolic syndrome risk by assessing complications across multiple systems. It provides targeted interventions at each stage to reduce metabolic syndrome risk and prevent disease progression.

What is a metabolic health check and how does it relate to ABCD?

A metabolic health check evaluates metabolic markers, organ-specific complications, and disease stage under the ABCD framework. It assesses risk factors and guides treatment decisions independent of BMI or appearance.